Effects of Human Prorenin in Rats Transgenic for Human Angiotensinogen
Population
Rats transgenic for human angiotensinogen (isolated perfused hindquarters and anesthetized in vivo models)
Comparison
Human prorenin vs Human renin alone, or saline injection
Design
Preclinical
Follow-up
15 minutes (short-term)
Authors
Discussion
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Member takes
Implication
Does not support prorenin as renin antagonist in vascular tissue; leaves open its role in human hypertension.
Structured PICO
P
Population
Rats transgenic for human angiotensinogen (isolated perfused hindquarters and anesthetized in vivo models)
I
Intervention
Human prorenin (infused alone or co-infused/co-injected with human renin)
C
Comparator
Human renin alone, or saline injection
O
Outcome
Angiotensin I release (as a parameter for renin uptake), mean arterial pressure (MAP), and plasma Angiotensin II levelssurrogate
Prorenin does not act as an endogenous antagonist for the long-lasting effects of renin in the vascular wall, nor does it affect acute renin-related blood pressure changes.
Cite This Study
Müller et al. (1999) studied this question.