Direct (pro)renin-induced effects via the (pro)renin receptor require supraphysiological concentrations, suggesting that direct renin-(P)RR interaction is unlikely to occur in nonrenin-synthesizing organs in vivo.
No takes yet. Share an insight, caveat, or question.
Challenges direct (P)RR effects at physiological levels in vivo; leaves open its role in nonrenin-synthesizing organs.
Batenburg et al. (2011) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: