January 21, 2011Journal of Hypertension

Prorenin induces vascular smooth muscle cell proliferation and hypertrophy via epidermal growth factor receptor-mediated extracellular signal-regulated kinase and Akt activation pathway

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Why the study?

Does prorenin induce proliferation and hypertrophy in vascular smooth muscle cells?

Population

Rat vascular smooth muscle cells (VSMCs)

Comparison

Recombinant rat prorenin vs Control or pretreatment with inhibitors (ERK…

Design

Preclinical

Authors

GLGang LiuHebei Medical University HHHirofumi HitomiKansai Medical University NHNaohisa HosomiHiroshima University

Discussion

Member takes

Implication

Supports (P)RR as VSMC growth mediator independent of Ang II; leaves open human relevance and in vivo validation.

Structured PICO

Does prorenin induce proliferation and hypertrophy in vascular smooth muscle cells?

Population

Rat vascular smooth muscle cells (VSMCs)

Intervention

Recombinant rat prorenin

Comparator

Control (untreated cells) or pretreatment with inhibitors (ERK kinase, PI3K, EGF receptor tyrosine kinase, Src inhibitor, (pro)renin receptor siRNA, candesartan, captopril)

Outcome

VSMC signal transduction (ERK 1/2 and Akt phosphorylation), proliferation (cell number, [H]-thymidine incorporation), and hypertrophy ([H]-leucine incorporation)surrogate

Prorenin directly stimulates vascular smooth muscle cell proliferation and hypertrophy via the (pro)renin receptor and EGF receptor-mediated pathways, independent of Angiotensin II.

Cite This Study

Liu et al. (2011) studied this question.

synapsesocial.com/papers/6a2030a460a84f4b7dd8d8fc https://doi.org/10.1097/hjh.0b013e328343c62b

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Prorenin induces vascular smooth muscle cell proliferation and hypertrophy via epidermal growth factor receptor-mediated extracellular signal-regulated kinase and Akt activation pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Prorenin induces vascular smooth muscle cell proliferation and hypertrophy via epidermal growth factor receptor-mediated extracellular signal-regulated kinase and Akt activation pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider