Population
human vascular smooth muscle cells (hVSMC)
Comparison
recombinant human prorenin vs control
Design
Preclinical
Authors
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Does not support altering RAAS blockade; leaves open (pro)renin receptor as Ang II-independent target in vascular remodeling.
Prorenin stimulates ERK phosphorylation in human vascular smooth muscle cells independently of angiotensin II, suggesting the (pro)renin receptor as a potential target for preventing vascular complications.
Sakoda et al. (2007) studied this question.
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