Population
Cultured rat vascular smooth muscle cells (VSMCs)
Comparison
Incubation with inactive prorenin (10 M) with or… vs Control conditions
Design
Preclinical
Authors
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Supports (p)RR as PAI-1 regulator in VSMCs; hypothesis-generating for diabetic vascular fibrosis, no clinical implications yet.
High concentrations of prorenin bind to the prorenin/renin receptor on vascular smooth muscle cells, leading to its activation and subsequent upregulation of the profibrotic molecule PAI-1, suggesting a mechanism for fibrotic disease progression in diabetes.
Zhang et al. (2008) studied this question.
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