What does this research mean for the field?

In the anesthetized guinea pig model, renin inhibitors and angiotensin II antagonists reduce blood pressure specifically through the renin-angiotensin system, whereas the ACE inhibitor captopril lowers blood pressure partially via a bradykinin-dependent mechanism. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1995Canadian Journal of Physiology and Pharmacology

Comparative studies on differential inhibition of the rennin–angiotensin system in the anesthetized guinea pig

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Why the study?

Does differential inhibition of the renin-angiotensin system reduce blood pressure in anesthetized guinea pigs?

Population

Anesthetized guinea pigs (urethane and ketamine)

Comparison

Angiotensin II receptor antagonist, renin… vs Vehicle

Design

Preclinical

Follow-up

1 hour following each increasing dose

Authors

JDJianmin DuanInversago Pharma (Canada)JJJorge JaramilloTulane University GJGrace L. JungUniversity of California, Berkeley

Discussion

Member takes

Implication

Captopril's greater effect is partly bradykinin-dependent in guinea pigs; hypothesis-generating for differential RAS inhibitor mechanisms in humans.

Structured PICO

Does differential inhibition of the renin-angiotensin system reduce blood pressure in anesthetized guinea pigs?

Population

Anesthetized guinea pigs (urethane and ketamine)

Intervention

Angiotensin II receptor antagonist (losartan), renin inhibitors (BILA 2157 BS and PD-134672), and ACE inhibitor (captopril) administered via i.v. bolus injection in increasing doses

Comparator

Vehicle

Outcome

Mean arterial blood pressure (MABP) and heart rate monitored for 1 h following each dosesurrogate

In a guinea pig model, renin inhibitors and AngII antagonists lower blood pressure specifically via the renin-angiotensin cascade, whereas captopril's greater hypotensive effect is partially bradykinin-dependent.

Cite This Study

Duan et al. (1995) studied this question.

synapsesocial.com/papers/6a12eaa083732aa7db9e8dc3 https://doi.org/10.1139/y95-209

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Implication

Captopril's greater effect is partly bradykinin-dependent in guinea pigs; hypothesis-generating for differential RAS inhibitor mechanisms in humans.

Comparative studies on differential inhibition of the rennin–angiotensin system in the anesthetized guinea pig

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparative studies on differential inhibition of the rennin–angiotensin system in the anesthetized guinea pig

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider