Why the study?
Do different renin-angiotensin system antagonists alter renal hemodynamics differently in normotensive guinea pigs?
Population
Anesthetized, ventilated normotensive guinea pigs
Comparison
DuP 753, MK 521, or Ro 42-5892 administered… vs Vehicle
Design
Preclinical
Follow-up
1 hour
Authors
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Renin inhibition may enhance renal hemodynamics more than ACEi or ARB in guinea pigs; leaves open translation to humans or disease states.
Do different renin-angiotensin system antagonists alter renal hemodynamics differently in normotensive guinea pigs?
In a guinea pig model, a human renin inhibitor produced greater improvements in renal hemodynamics than an ACE inhibitor or Ang II receptor antagonist for a similar reduction in blood pressure.
Amrani et al. (1993) studied this question.
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