Population
Animal models including rabbits, rats, cats, guinea pigs, and dogs, as well as guinea pig plasma
Design
Preclinical
Authors
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Potent preclinical ACE inhibition observed; extends animal data but leaves open human translation and trials.
S 9490 and its diacid form S 9780 demonstrate potent angiotensin-converting enzyme inhibition and blood pressure lowering effects in preclinical animal models.
Laubie et al. (1984) studied this question.
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