Key result
S-9490-3 reduces blood pressure and inhibits ACE more than enalapril in hypertensive rats.
Population
Conscious, chronically cannulated Na+-replete and Na+-deplete spontaneously hypertensive rats of the Okamoto…
Comparison
Single oral dose of S-9490-3 vs Single oral dose of enalapril or vehicle
Design
Preclinical
Follow-up
24 hours
Authors
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Supports further preclinical development of S-9490-3; leaves open translation of superior ACE inhibition to human hypertension.
In a spontaneously hypertensive rat model, the ACE inhibitor S-9490-3 demonstrated greater hypotensive efficacy and ACE inhibition compared to enalapril.
DiNicolantonio et al. (1985) studied Hypertension. S-9490-3 vs. Enalapril and vehicle was evaluated on Blood pressure, plasma ACE activity, plasma renin activity, and pressor responses to intravenous bolus injections of angiotensin I. S-9490-3 caused a significantly greater hypotensive response and inhibition of plasma ACE and AI pressor responses than enalapril in spontaneously hypertensive rats.
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