Why the study?
Does chronic administration of ACE inhibitors (enalapril, CGS 14824A, CGS 16617) reduce blood pressure and alter tissue ACE activity in conscious SHR?
Population
Conscious Spontaneously Hypertensive Rats (SHR)
Design
Preclinical
Authors
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May guide tissue ACE mechanistic studies in SHR models; leaves open translation to human hypertension therapy.
Does chronic administration of ACE inhibitors (enalapril, CGS 14824A, CGS 16617) reduce blood pressure and alter tissue ACE activity in conscious SHR?
This preclinical study investigates the mechanisms of blood pressure reduction by ACE inhibitors, focusing on tissue ACE activity rather than circulating enzyme levels.
Zimmerman et al. (1987) studied this question.
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