What question did this study set out to answer?

To determine whether ACE inhibitors reduce vascular angiotensin II release in mesenteric arteries and lower blood pressure in spontaneously hypertensive rats.

January 1, 1991American Journal of Hypertension

Angiotensin Converting Enzyme Inhibitors Suppress the Vascular Renin - Angiotensin System of Spontaneously Hypertensive Rats

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Why the study?

Do ACE inhibitors reduce blood pressure and suppress vascular angiotensin II release in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHRs) and their isolated mesenteric arteries

Comparison

ACE inhibitors administered orally for 1 week vs Control

Design

Preclinical

Follow-up

1 week

Authors

KHKoichi HigashimoriThe University of Osaka MNMitsuaki NakamaruKawamura Hospital YTYoshikatsu TabuchiThe University of Osaka

Discussion

Member takes

Implication

Supports tissue RAS role in rat hypertension models; leaves open translation to human ACE inhibitor mechanisms.

Key Points

To determine whether ACE inhibitors reduce vascular angiotensin II release in mesenteric arteries and lower blood pressure in spontaneously hypertensive rats.
Evaluated the dose-dependent effects of delapril, enalapril, and captopril on angiotensin II release from isolated mesenteric arteries of spontaneously hypertensive rats.
Treated spontaneously hypertensive rats orally for one week with delapril (10 mg/kg/day), enalapril (10 mg/kg/day), captopril (50 mg/kg/day), or low-dose captopril (10 mg/kg/day).
Delapril, enalapril, and captopril suppressed angiotensin II release from isolated mesenteric arteries in a dose-dependent manner.
One-week oral therapy significantly reduced blood pressure and decreased basal vascular angiotensin II release by 54% with delapril (10 mg/kg/day), 46% with enalapril (10 mg/kg/day), and 36% with captopril (50 mg/kg/day) compared to control.
Low-dose captopril (10 mg/kg/day) showed no effect on blood pressure or basal vascular angiotensin II release.

Structured PICO

Do ACE inhibitors reduce blood pressure and suppress vascular angiotensin II release in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHRs) and their isolated mesenteric arteries

Intervention

ACE inhibitors (delapril 10 mg/kg/day, enalapril 10 mg/kg/day, captopril 50 mg/kg/day, or captopril 10 mg/kg/day) administered orally for 1 week

Comparator

Control

Outcome

Blood pressure and basal angiotensin II (Ang II) release from isolated mesenteric arteriessurrogate

ACE inhibitors suppress vascular renin-angiotensin activity and reduce blood pressure in spontaneously hypertensive rats, suggesting the tissue renin-angiotensin system contributes to spontaneous hypertension.

Cite This Study

Higashimori et al. (1991) studied this question.

synapsesocial.com/papers/6a70836dac440176ef292deb https://doi.org/10.1093/ajh/4.1.56s

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Angiotensin Converting Enzyme Inhibitors Suppress the Vascular Renin - Angiotensin System of Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Angiotensin Converting Enzyme Inhibitors Suppress the Vascular Renin - Angiotensin System of Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider