Why the study?
Do renin inhibitors and ACE inhibitors suppress vascular renin activity and Angiotensin II release in isolated perfused rat mesenteric arteries?
Population
Isolated perfused rat mesenteric arteries
Comparison
N-acetyl-pepstatin (5 X 10-5 X 10 M) and five… vs Basal values and isoproterenol alone
Design
Preclinical
Authors
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Supports local vascular RAS suppression by renin/ACE inhibitors in rats; hypothesis-generating and should not change practice.
Do renin inhibitors and ACE inhibitors suppress vascular renin activity and Angiotensin II release in isolated perfused rat mesenteric arteries?
Renin inhibitors and ACE inhibitors suppress locally generated Angiotensin II in the vascular renin-angiotensin system, which may contribute to their hypotensive actions.
Saitō et al. (1989) studied this question.
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