Why the study?
Does chronic oral administration of ACE inhibitors inhibit the vascular renin-angiotensin system in male Sprague-Dawley rats?
Population
Male Sprague-Dawley rats
Design
Preclinical
Follow-up
1-2 weeks
Authors
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Inhibits vascular AII release after chronic ACEI in rats; leaves open contribution to human antihypertensive effects.
Does chronic oral administration of ACE inhibitors inhibit the vascular renin-angiotensin system in male Sprague-Dawley rats?
Prolonged treatment with ACE inhibitors virtually completely inhibits the vascular renin-angiotensin system, suggesting their chronic antihypertensive action is not solely due to plasma renin-angiotensin system inhibition.
Saitō et al. (1990) studied this question.
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