Key result
In spontaneously hypertensive rats, all four ACE inhibitors significantly reduced blood pressure and aorta ACE activities, but only trandolapril and perindopril significantly reduced cardiac hypertrophy.
Why the study?
Does treatment with different ACE inhibitors reduce blood pressure and cardiac hypertrophy through specific tissue ACE activities in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR)
Design
Preclinical
Follow-up
2 weeks
Authors
Loading...
Rat data on ACE inhibitors should not change practice; leaves open differential tissue effects in human hypertension.
Does treatment with different ACE inhibitors reduce blood pressure and cardiac hypertrophy through specific tissue ACE activities in spontaneously hypertensive rats?
p-value: p=<0.05
The hypotensive and anti-hypertrophic effects of ACE inhibitors correlate with their ability to suppress ACE activity in vascular tissues and the heart, respectively.
Takai et al. (2004) studied Hypertension and cardiac hypertrophy (n=30). ACE inhibitors (trandolapril, temocapril, perindopril, enalapril) vs. Placebo was evaluated on Blood pressure and tissue ACE activities (p=<0.05). In spontaneously hypertensive rats, all four ACE inhibitors significantly reduced blood pressure and aorta ACE activities, but only trandolapril and perindopril significantly reduced cardiac hypertrophy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: