What is the clinical evidence from this study?

Population: Hypertension (n=53). Intervention: Delapril vs. Vehicle (5% arabic gum). Primary outcome: Left ventricular weight (therapeutic protocol) (p=<0.05).

What question did this study set out to answer?

To investigate the differential effects of angiotensin-converting enzyme inhibitors on cardiac versus vascular hypertrophy and to assess the relationship with arginine vasopressin levels.

January 1, 2000Hypertension ResearchOpen Access

Non-Corresponding Effects of an Angiotensin-Converting Enzyme Inhibitor on Cardiac and Vascular Hypertrophy in Spontaneously Hypertensive Rats.

Q: What are the key findings of this study?

Delapril significantly reduced left ventricular weight compared to control (64 vs 69 mg/100 g body weight, p<0.05) in spontaneously hypertensive rats, but did not reduce vascular hypertrophy.

Q: What question did this study set out to answer?

To investigate the differential effects of angiotensin-converting enzyme inhibitors on cardiac versus vascular hypertrophy and to assess the relationship with arginine vasopressin levels.

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Key result

Delapril significantly reduced left ventricular weight compared to control (64 vs 69 mg/100 g body weight, p<0.05) in spontaneously hypertensive rats, but did not reduce vascular hypertrophy.

Why the study?

Does delapril reduce cardiac and vascular hypertrophy in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR)

Comparison

Delapril 30 mg/kg/day administered in a… vs Vehicle (5% arabic gum)

Design

Preclinical

Follow-up

Up to 24 weeks

Authors

MTMasahiko TozawaThird Way STShuichi TakishitaKagoshima University HMHiromi MurataniKyushu Sangyo University

Discussion

Member takes

Implication

No clinical implications; hypothesis-generating for differential cardiac versus vascular hypertrophy responses in hypertension models.

Key Points

To investigate the differential effects of angiotensin-converting enzyme inhibitors on cardiac versus vascular hypertrophy and to assess the relationship with arginine vasopressin levels.
Spontaneously hypertensive rats were treated with delapril (30 mg/kg/day) or vehicle from 4 to 28 weeks of age (preventive) and from 12 to 24 weeks of age (therapeutic).
Evaluated systolic blood pressure, left ventricular weight, and plasma renin activity in both treatment protocols.
In the therapeutic protocol, left ventricular weight was significantly lower in the ACEI group at 64+/-2 mg/100 g body weight compared to 69+/-1 mg/100 g body weight in the control (p<0.05).
Plasma renin activity increased significantly in the ACEI group in both preventive (p <0.01) and therapeutic protocols (p<0.01).
Arginine vasopressin concentration was significantly lower in the ACEI group (p<0.05) and was correlated with left ventricular weight (p=0.02, r=0.46).

Structured PICO

Does delapril reduce cardiac and vascular hypertrophy in spontaneously hypertensive rats?

Population

53 male spontaneously hypertensive rats were treated with delapril or vehicle in preventive or therapeutic protocols to assess effects on cardiac and vascular hypertrophy.

Intervention

Delapril (ACEI) 30 mg/kg/day administered in a preventive (4 to 28 weeks of age) or a therapeutic (12-24 weeks of age) protocol

Comparator

Vehicle (5% arabic gum)

Outcome

Hypertrophy of the heart and hypertrophy of the coronary and renal interlobular arteriessurrogate

Main Result

Absolute Event Rate: 64% vs 69%

p-value: p=<0.05

Delapril reduces cardiac hypertrophy but not coronary and renal artery hypertrophy in spontaneously hypertensive rats, with arginine vasopressin potentially playing a role in cardiac hypertrophy etiology.

Limitations

Animal model (SHR) may not fully translate to human hypertension
Use of 1% NaCl in drinking water made hypertension relatively refractory to ACEI administration, resulting in only mild blood pressure reduction

Cite This Study

Tozawa et al. (2000) studied Hypertension (n=53). Delapril vs. Vehicle (5% arabic gum) was evaluated on Left ventricular weight (therapeutic protocol) (p=<0.05). Delapril significantly reduced left ventricular weight compared to control (64 vs 69 mg/100 g body weight, p<0.05) in spontaneously hypertensive rats, but did not reduce vascular hypertrophy.

synapsesocial.com/papers/6a20bf956aba112f1d337997 https://doi.org/10.1291/hypres.23.483

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Non-Corresponding Effects of an Angiotensin-Converting Enzyme Inhibitor on Cardiac and Vascular Hypertrophy in Spontaneously Hypertensive Rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Limitations

Cite This Study

Non-Corresponding Effects of an Angiotensin-Converting Enzyme Inhibitor on Cardiac and Vascular Hypertrophy in Spontaneously Hypertensive Rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Limitations

Cite This Study

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