Why the study?
Does perindopril prevent age-related cardiac hypertrophy and action potential duration changes in aging normotensive male WAG/Rij rats?
Population
Normotensive male WAG/Rij rats (aging model, up to 30 months old)
Comparison
Perindopril short-term treatment for 1 month vs Untreated/control aging rats
Design
Preclinical
Follow-up
1 month
Authors
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Highlights potential dissociation between hypertrophy and APD remodeling in aging; hypothesis-generating and should not yet influence clinical practice.
Does perindopril prevent age-related cardiac hypertrophy and action potential duration changes in aging normotensive male WAG/Rij rats?
ACE inhibition prevents age-related cardiac hypertrophy but not action potential prolongation in aging rats, suggesting a dissociation between cardiac mass and electrophysiological changes during aging.
Kreher et al. (1995) studied this question.
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