March 1, 1994AJP Regulatory Integrative and Comparative Physiology

Effect of chronic ANG I-converting enzyme inhibition on aging processes. I. Kidney structure and function

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Why the study?

Does perindopril prevent age-related changes in kidney structure and function in normotensive male Wistar rats?

Population

Normotensive male Wistar (WAG)/Rij rats

Comparison

Perindopril administered from the age of 6… vs Untreated control rats (implied)

Design

Preclinical

Follow-up

Up to 24 months (from age 6 months to 30 months)

Authors

DHDidier HeudesUniversité Claude Bernard Lyon 1 OMOlaf MichelTH Köln - University of Applied Sciences JCJulie ChevalierLaboratoire de psychologie clinique, psychopathologie, psychanalyse

Discussion

Member takes

Implication

Does not support clinical use in human renal aging; leaves open translation from rat models.

Structured PICO

Does perindopril prevent age-related changes in kidney structure and function in normotensive male Wistar rats?

Population

Normotensive male Wistar (WAG)/Rij rats

Intervention

Perindopril administered from the age of 6 months to the day of killing at 12, 24, or 30 months

Comparator

Untreated control rats (implied)

Outcome

Age-related changes in kidney structure and functionsurrogate

Chronic ACE inhibition with perindopril delays specific age-related functional and structural declines in the kidneys of normotensive rats.

Cite This Study

Heudes et al. (1994) studied this question.

synapsesocial.com/papers/6a70952c26a7f98052dd0fee https://doi.org/10.1152/ajpregu.1994.266.3.r1038

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Effect of chronic ANG I-converting enzyme inhibition on aging processes. I. Kidney structure and function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of chronic ANG I-converting enzyme inhibition on aging processes. I. Kidney structure and function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider