Why the study?
Does acute converting-enzyme inhibition alter arterial pressure and kidney hemodynamics in aging normotensive female rats?
Population
Normotensive 3-, 10-, 20-, and 30-month-old female Wistar rats
Design
Preclinical
Follow-up
acute
Authors
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ACE inhibition lowers BP and raises renal clearance in younger but not senescent rats; leaves open age-related RAS relevance in humans.
Does acute converting-enzyme inhibition alter arterial pressure and kidney hemodynamics in aging normotensive female rats?
The renin-angiotensin system's activity declines with age, suggesting angiotensin II is not critical for maintaining blood pressure and kidney hemodynamics in senescent female rats.
Corman et al. (1986) studied this question.
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