Changes seen in the aging kidney and the effect of blocking the renin—angiotensin system

74 Wistar rats (30 starting treatment after weaning, 24 starting at 12 months of age, and 20 healthy controls evaluated at 7 and 12 months)

Losartan 30 mg/kg/day or enalapril 10 mg/kg/day starting either after weaning or at 12 months of age, continued until 18 months of age

Control group (no treatment)

Glomerular structural changes (focal and periglomerular sclerosis, mesangial matrix expansion, glomerular area) and renal function (proteinuria, serum creatinine) at 18 months of agesurrogate