Why the study?
Do enalapril or losartan attenuate age-associated changes in kidney mitochondria in aged rats?
Population
Male Wistar rats (14 months old at baseline) and 4-month-old untreated rats (Young)
Comparison
Enalapril or losartan in drinking water for 8… vs Untreated aged rats and untreated 4-month-old rats
Design
Preclinical
Follow-up
8 months
Authors
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Should not yet change clinical practice for age-related kidney protection; leaves open translation of RAS inhibition benefits from rat mitochondria to humans.
Do enalapril or losartan attenuate age-associated changes in kidney mitochondria in aged rats?
Enalapril and losartan protect against age-related mitochondrial dysfunction and ultrastructural alterations in the kidneys of aged rats, suggesting a role for RAS inhibition in modulating oxidative stress during aging.
Cavanagh et al. (2003) studied this question.
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