Key result
Early aging in rats is associated with a modest but important increase in sensitivity to renin-angiotensin system stimulation, with exaggerated reductions in glomerular filtration and plasma flow.
Why the study?
Does aging alter the activity and responsiveness of the systemic and intrarenal renin-angiotensin system in rats?
Population
Young (3 months) and early aging (15 months) male Sprague-Dawley rats
Comparison
Angiotensin-converting enzyme inhibitors and… vs Young versus early aging rats
Design
Preclinical
Authors
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May suggest caution with RAS agents in early aging; hypothesis-generating for human renal aging research.
Does aging alter the activity and responsiveness of the systemic and intrarenal renin-angiotensin system in rats?
Early aging in rats is associated with increased renal sensitivity to renin-angiotensin system stimulation despite comparable systemic blood pressure responses.
Thompson et al. (2000) studied Aging. Angiotensin-converting enzyme inhibitors and ANG I infusion vs. Young vs early aging rats was evaluated on Systemic and intrarenal RAS status, mean arterial pressure, and renal function. Early aging in rats is associated with a modest but important increase in sensitivity to renin-angiotensin system stimulation, with exaggerated reductions in glomerular filtration and plasma flow.
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