Key result
Chronic ACE inhibition with perindopril lowered blood pressure but did not prevent age-dependent large artery enlargement and stiffening in normotensive rats.
Why the study?
Does chronic perindopril treatment prevent age-related arterial structural and functional changes in normotensive rats?
Population
Normotensive male WAG/Rij rats evaluated at 6, 12, 24, and 30 months of age
Comparison
Chronic angiotensin-converting enzyme inhibitor vs Untreated control group of similar normotensive…
Design
Preclinical
Follow-up
up to 30 months of age
Authors
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Aging alters arterial structure in normotensive rats independently of pressure; leaves open relevance to human hypertension and aging.
Does chronic perindopril treatment prevent age-related arterial structural and functional changes in normotensive rats?
Chronic ACE inhibition delays medial and intimal thickening but does not prevent age-dependent large artery enlargement and stiffening in normotensive rats, suggesting aging and blood pressure affect arterial walls via different mechanisms.
Michel et al. (1994) studied Aging and arterial structure/function (n=20). Perindopril vs. Untreated control rats was evaluated on Arterial function and wall structure. Chronic ACE inhibition with perindopril lowered blood pressure but did not prevent age-dependent large artery enlargement and stiffening in normotensive rats.
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