Population
Rats (from newborn to senescent, up to 30 months of age), specifically assessing isolated carotid arteries
Comparison
Aging (observation from newborn to senescence) vs Younger age groups (newborn/young rats)
Design
Preclinical
Follow-up
up to 30 months of age
Authors
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Rat arterial remodeling data do not inform human hypertension care; leaves open whether contractile capacity rises drive age-related vascular changes.
Normal aging induces arterial wall remodeling and smooth muscle thickening in rats, leading to increased contractile capacity that is independent of systemic blood pressure.
Ivić et al. (2016) studied this question.
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