Why the study?
Does aging increase arterial stiffness and alter structural composition in rat carotid arteries?
Population
6- and 23-month-old Brown Norway X Fischer 344 rats
Comparison
Aging (23-month-old rats) vs Young age (6-month-old rats)
Design
Preclinical
Authors
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Aged rat data should not change clinical hypertension practice; extends preclinical models of age-related vascular remodeling.
Does aging increase arterial stiffness and alter structural composition in rat carotid arteries?
Aging in a rat model is associated with significant increases in both active and passive arterial stiffness, driven by structural alterations including increased collagen and decreased elastin.
Gaballa et al. (1998) studied this question.
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