Central Arterial Aging and Angiotensin II Signaling
Population
Rats, nonhuman primates, and humans (in vitro and in vivo studies on central arterial aging)
Design
Review
Authors
Discussion
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Member takes
Implication
Potential therapeutic target for arterial aging; leaves open whether ACEi/ARB benefits extend beyond BP control in normotensives.
Structured PICO
P
Population
Rats, nonhuman primates, and humans (in vitro and in vivo studies on central arterial aging)
I
Intervention
Modulation of Angiotensin II signaling (ACE inhibition or AT1 blockade)
Angiotensin II signaling plays a central role in age-associated arterial remodeling, making it a potential therapeutic target for arterial aging.
Cite This Study
Wang et al. (2010) studied this question.