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April 24, 2007HypertensionOpen Access

Proinflammatory Profile Within the Grossly Normal Aged Human Aortic Wall

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Why the study?

Does aging alter the proinflammatory profile and remodeling markers in grossly normal human thoracic aortas?

Population

10 grossly normal thoracic aortas harvested at necropsy from 5 young and 5 old white males who died from…

Comparison

Aging and in vitro exposure of isolated smooth… vs Young aortas; in vitro cells without angiotensin…

Design

Preclinical

Authors

MWMingyi WangJZJing ZhangLJLi-Qun Jiang

Discussion

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Overview

Aging-linked aortic inflammation and remodeling in animals leaves open translation to human hypertension or atherosclerosis risk.

Structured PICO

Does aging alter the proinflammatory profile and remodeling markers in grossly normal human thoracic aortas?

P
Population
10 grossly normal thoracic aortas harvested at necropsy from 5 young (20+/-3 years) and 5 old (65+/-6 years) white males who died from traumatic causes.
I
Intervention
Aging (old vs young aortas) and in vitro exposure of isolated smooth muscle cells to angiotensin II.
C
Comparator
Young aortas; in vitro cells without angiotensin II or treated with metalloproteinase inhibitor or angiotensin II receptor blocker.
O
Outcome
Levels of proinflammatory and remodeling markers (ACE, Ang II, AT1R, MMP 2/9, MCP-1, collagen I/III) and intimal thickness in the aortic wall.surrogate

The grossly normal aged human aortic wall develops a proinflammatory and pro-remodeling profile independent of lipid infiltration, potentially predisposing to atherosclerosis and hypertension.

Cite This Study

Wang et al. (2007) studied this question.

synapsesocial.com/papers/69d57420cb7e4bf698cf40c3https://doi.org/10.1161/hypertensionaha.107.089409
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