Key result
Replicative aging of human aortic endothelial cells increased smooth muscle alpha actin and type I collagen expression (P<0.05), indicating a transition to a mesenchymal phenotype.
Population
Human aortic endothelial cells
Comparison
Replicative aging vs Early population doublings ('young' cells)
Design
Preclinical
Authors
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May implicate endothelial-to-mesenchymal transition in age-related stiffening; hypothesis-generating in vitro data requiring in vivo confirmation.
p-value: p=< 0.05
Replicative aging induces a vascular endothelial to mesenchymal cell transition in human aortic endothelial cells, potentially contributing to arterial stiffening.
Fleenor et al. (2010) studied Arterial stiffening. Replicative aging (late population doublings) vs. Early population doublings was evaluated on Smooth muscle alpha actin (SMαA) and type I collagen protein expression (p=< 0.05). Replicative aging of human aortic endothelial cells increased smooth muscle alpha actin and type I collagen expression (P<0.05), indicating a transition to a mesenchymal phenotype.
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