Key result
Aging impairs the regulation of the vascular smooth muscle cell component of aortic stiffness through focal adhesion signaling, diminishing the aorta's normal shock absorption function.
Effect estimate: 16% decrease
p-value: p=<0.001
Vascular smooth muscle cells significantly contribute to aortic stiffness, and their regulation through focal adhesion signaling is impaired with aging, diminishing the aorta's shock absorption function.
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Does not warrant clinical practice changes; leaves open whether focal adhesion signaling modulates aortic stiffness in aging humans.
Gao et al. (2014) studied Aortic stiffness (n=25). Aging vs. Young mice was evaluated on Baseline aortic material stiffness (16% decrease, p=<0.001). Aging impairs the regulation of the vascular smooth muscle cell component of aortic stiffness through focal adhesion signaling, diminishing the aorta's normal shock absorption function.
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