Key result
Hypertension increased both vascular smooth muscle cell stiffness and adhesion, and these increases were augmented with aging.
Why the study?
Does hypertension superimposed on aging increase vascular smooth muscle cell stiffness and adhesion in rat models?
Does hypertension superimposed on aging increase vascular smooth muscle cell stiffness and adhesion in rat models?
Increased vascular smooth muscle cell stiffness and adhesion are novel mechanisms contributing to aortic stiffness in hypertension superimposed on aging.
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Does not support practice changes in aging hypertensives; leaves open translation of VSMC mechanisms to human aortic stiffness.
Sehgel et al. (2014) studied Hypertension and aging. Hypertension vs. Wistar-Kyoto wild-type controls was evaluated on Vascular smooth muscle cell stiffness and adhesion. Hypertension increased both vascular smooth muscle cell stiffness and adhesion, and these increases were augmented with aging.
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