July 16, 2010Circulation ResearchOpen Access

Short Communication: Vascular Smooth Muscle Cell Stiffness As a Mechanism for Increased Aortic Stiffness With Aging

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Why the study?

Does aging increase the intrinsic stiffness of vascular smooth muscle cells?

Population

Vascular smooth muscle cells from aorta of young versus old male monkeys

Comparison

Aging (old monkeys) vs Young monkeys

Design

Preclinical

Authors

HQHongyu QiuUniversity of Arizona YZYi ZhuUniversity of Alabama at Birmingham ZSZhe SunTianjin University

Discussion

Member takes

Implication

Adds VSMC stiffness to vascular aging mechanisms; challenges ECM-centric views but leaves open human translation.

Structured PICO

Does aging increase the intrinsic stiffness of vascular smooth muscle cells?

Population

Vascular smooth muscle cells (VSMCs) from aorta of young versus old male monkeys (Macaca fascicularis) (n=7/group)

Intervention

Aging (old monkeys)

Comparator

Young monkeys

Outcome

Cellular stiffness measured in vitro by atomic force microscopy (AFM) and in a reconstituted tissue modelsurrogate

Increased vascular stiffness with aging is attributable not only to extracellular matrix changes but also to intrinsic stiffening of vascular smooth muscle cells.

Cite This Study

Qiu et al. (2010) studied this question.

synapsesocial.com/papers/6a724eca5671bbf00bc30c6b https://doi.org/10.1161/circresaha.110.221846

View Full Paper

Ask AI

Bookmark

Short Communication: Vascular Smooth Muscle Cell Stiffness As a Mechanism for Increased Aortic Stiffness With Aging

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Short Communication: Vascular Smooth Muscle Cell Stiffness As a Mechanism for Increased Aortic Stiffness With Aging

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider