Key result
Vascular smooth muscle cells play a significant role in the etiology of aortic stiffening across different spatial scales, alongside changes in extracellular matrix protein composition.
This review highlights the emerging role of contractile vascular smooth muscle cells in age-related aortic stiffening, expanding upon the traditional view that it is solely driven by extracellular matrix changes.
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Challenges ECM-centric view of aortic stiffening; leaves open VSMC-targeted interventions pending prospective validation.
Saphirstein et al. (2013) conducted a review in Aortic stiffness. Vascular smooth muscle cells play a significant role in the etiology of aortic stiffening across different spatial scales, alongside changes in extracellular matrix protein composition.
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