Key result
Age-associated vascular smooth muscle cell stiffness contributes to aortic stiffening via cytoskeletal and adhesion changes.
Why the study?
Vascular aging, aortic stiffness, and hypertension are mechanistically interrelated, warranting a focus on the molecular mechanisms of age-associated increases in vascular smooth muscle cell stiffness.
This review highlights the molecular mechanisms by which vascular smooth muscle cell stiffness contributes to vascular aging and aortic stiffness.
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Should not alter vascular aging management; supports mechanistic research but leaves open clinical translation.
Kajuluri et al. (2021) conducted a review in Vascular aging and aortic stiffness. Age-associated increases in vascular smooth muscle cell stiffness, driven by changes in the cytoskeleton and focal adhesion dynamics, significantly contribute to overall aortic stiffening.
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