May 12, 2006Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Matrix Metalloproteinase 2 Activation of Transforming Growth Factor-β1 (TGF-β1) and TGF-β1–Type II Receptor Signaling Within the Aged Arterial Wall

Q: What is the clinical evidence from this study?

Study design: Other. Population: Arterial aging. Intervention: Aging and MMP-2 activation vs. Young rats (8 months) and untreated cells. Primary outcome: TGF-beta1 activation status and downstream signaling.

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Population

Fisher 344 cross-bred Brown Norway rats, young aortic rings ex vivo, and vascular smooth muscle cells in vitro

Comparison

Incubation with activated MMP-2 or MMP-2… vs Untreated young or old counterparts

Design

Preclinical

Key result

Aging and MMP-2 activation increased active TGF-beta1 and its receptor-mediated signaling within the aortic wall, suggesting a novel molecular mechanism for arterial aging.

Authors

MWMingyi Wang DZDi Zhao GSGaia Spinetti

Discussion

Member takes

Overview

MMP-2 modulation of aortic TGF-beta1 signaling in aged rats extends mechanistic insights; leaves open any role in human vascular aging or therapy.

Structured PICO

Population

Fisher 344 cross-bred Brown Norway rats (30 months vs 8 months of age) and vascular smooth muscle cells used to study arterial aging.

Exposure

Incubation with activated MMP-2 or MMP-2 inhibitors

Comparator

Untreated young or old counterparts

Outcome

TGF-beta1 activation status and downstream signaling (TbetaRII, SMAD2/3, SMAD4, fibronectin, collagen)surrogate

MMP-2-dependent activation of TGF-beta1 and subsequent TbetaRII signaling represents a novel molecular mechanism underlying arterial aging.

Cite This Study

Wang et al. (2006) studied Arterial aging. Aging and MMP-2 activation vs. Young rats (8 months) and untreated cells was evaluated on TGF-beta1 activation status and downstream signaling. Aging and MMP-2 activation increased active TGF-beta1 and its receptor-mediated signaling within the aortic wall, suggesting a novel molecular mechanism for arterial aging.

synapsesocial.com/papers/6a5b698a632606eed5f6f806 https://doi.org/10.1161/01.atv.0000225777.58488.f2

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May 12, 2006Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Matrix Metalloproteinase 2 Activation of Transforming Growth Factor-β1 (TGF-β1) and TGF-β1–Type II Receptor Signaling Within the Aged Arterial Wall

View Full Paper

Ask AI

Bookmark

Population

Fisher 344 cross-bred Brown Norway rats, young aortic rings ex vivo, and vascular smooth muscle cells in vitro

Comparison

Incubation with activated MMP-2 or MMP-2… vs Untreated young or old counterparts

Design

Preclinical

Key result

Aging and MMP-2 activation increased active TGF-beta1 and its receptor-mediated signaling within the aortic wall, suggesting a novel molecular mechanism for arterial aging.

Authors

MWMingyi Wang DZDi Zhao GSGaia Spinetti

Discussion

Member takes

Overview

MMP-2 modulation of aortic TGF-beta1 signaling in aged rats extends mechanistic insights; leaves open any role in human vascular aging or therapy.

Structured PICO

Population

Fisher 344 cross-bred Brown Norway rats (30 months vs 8 months of age) and vascular smooth muscle cells used to study arterial aging.

Exposure

Incubation with activated MMP-2 or MMP-2 inhibitors

Comparator

Untreated young or old counterparts

Outcome

TGF-beta1 activation status and downstream signaling (TbetaRII, SMAD2/3, SMAD4, fibronectin, collagen)surrogate

MMP-2-dependent activation of TGF-beta1 and subsequent TbetaRII signaling represents a novel molecular mechanism underlying arterial aging.

Cite This Study

synapsesocial.com/papers/6a5b698a632606eed5f6f806 https://doi.org/10.1161/01.atv.0000225777.58488.f2

View Full Paper

Ask AI

Bookmark