What is the clinical evidence from this study?

Population: Spontaneously hypertensive rats (SHRs). Intervention: ACE inhibitors (captopril, enalapril, fosinopril, ramipril). Primary outcome: Left ventricular and media hypertrophy, ACE activity and plasma endothelin-1 concentrations.

What question did this study set out to answer?

To compare the efficacy of chemically distinct ACE inhibitors in reducing left ventricular and vascular media hypertrophy, tissue ACE activity, and endothelin-1 levels in spontaneously hypertensive rats.

December 1, 2002Journal of Hypertension

Regression of ventricular and vascular hypertrophy

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Key result

ACE inhibitors uniformly reduced cardiovascular hypertrophy in spontaneously hypertensive rats, with high doses decreasing left ventricular weight by 17-19% and aortic media thickness by 26-32%.

Why the study?

Do chemically different ACE inhibitors uniformly reduce cardiovascular hypertrophy in spontaneously hypertensive rats?

Key Points

To compare the efficacy of chemically distinct ACE inhibitors in reducing left ventricular and vascular media hypertrophy, tissue ACE activity, and endothelin-1 levels in spontaneously hypertensive rats.
Spontaneously hypertensive rats received 3-month regimens of captopril (2 x 25 mg/kg/day), enalapril (10 mg/kg/day), fosinopril (20 mg/kg/day), or ramipril (1 mg/kg/day) at full doses or 1% low doses.
Blood pressure, left ventricular weight, aortic media thickness, plasma endothelin-1, and tissue ACE activity in heart, aorta, and kidney were evaluated, alongside an AT1-receptor antagonist control.
High-dose captopril, enalapril, fosinopril, and ramipril reduced systolic blood pressure (-61, -54, -35, and -47 mmHg) and decreased left ventricular weight (-17%, -19%, -17%, and -19%), while 1% doses had no effect on these measures.
Aortic media thickness decreased significantly with both high doses (-31%, -32%, -27%, -26%) and low doses (-16%, -22%, -22%, -19%), accompanied by reduced tissue ACE activity without altering plasma endothelin-1.

Structured PICO

Do chemically different ACE inhibitors uniformly reduce cardiovascular hypertrophy in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats treated for 3 months with captopril, enalapril, fosinopril or ramipril to evaluate cardiovascular hypertrophy.

Intervention

Captopril, enalapril, fosinopril or ramipril (high doses: 2 x 25, 10, 20 or 1 mg/kg per day; low doses: corresponding 1% doses) for 3 months

Outcome

Left ventricular and media hypertrophy, ACE activity and plasma endothelin-1 concentrationssurrogate

ACE inhibitors uniformly reduce cardiovascular hypertrophy, demonstrating a class effect that includes blood pressure-independent antihypertrophic effects in the aorta.

Discussion

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Implication

Supports class effect on hypertrophy in rats; leaves open translation to human hypertension therapy.

Cite This Study

Raasch et al. (2002) studied Spontaneously hypertensive rats (SHRs). ACE inhibitors (captopril, enalapril, fosinopril, ramipril) was evaluated on Left ventricular and media hypertrophy, ACE activity and plasma endothelin-1 concentrations. ACE inhibitors uniformly reduced cardiovascular hypertrophy in spontaneously hypertensive rats, with high doses decreasing left ventricular weight by 17-19% and aortic media thickness by 26-32%.

synapsesocial.com/papers/6a903a19d68f3313dd8410fb https://doi.org/10.1097/00004872-200212000-00030

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Regression of ventricular and vascular hypertrophy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Regression of ventricular and vascular hypertrophy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider