Key result
Enalapril and hydralazine prevented medial hypertrophy in the superior mesenteric artery and resistance vessels in stroke-prone spontaneously hypertensive rats.
Why the study?
Does enalapril or hydralazine prevent cardiovascular hypertrophy in stroke-prone spontaneously hypertensive rats?
Does enalapril or hydralazine prevent cardiovascular hypertrophy in stroke-prone spontaneously hypertensive rats?
In a rat model of hypertension, ACE inhibition prevents vascular and ventricular hypertrophy, but persistent structural changes do not explain long-term blood pressure suppression after treatment withdrawal.
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May limit vascular hypertrophy in experimental hypertension; leaves open translation to human disease and practice.
King et al. (1992) studied Hypertension. Enalapril or hydralazine was evaluated on Left ventricular hypertrophy and structural indices of the superior mesenteric artery and its resistance vessels. Enalapril and hydralazine prevented medial hypertrophy in the superior mesenteric artery and resistance vessels in stroke-prone spontaneously hypertensive rats.
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