Why the study?
Does enalapril improve cardiovascular structural changes compared to hydrochlorothiazide in previously untreated men with essential hypertension?
Population
28 previously untreated men with essential nonmalignant hypertension and a supine casual diastolic blood…
Comparison
Enalapril for 6 months vs Hydrochlorothiazide for 6 months
Design
RCT, randomized, double-blind
Follow-up
6 months
Authors
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Enalapril may be preferred over hydrochlorothiazide for reversing cardiac and vascular remodeling in hypertension; extends evidence that RAAS blockade confers benefits beyond BP reduction.
Does enalapril improve cardiovascular structural changes compared to hydrochlorothiazide in previously untreated men with essential hypertension?
Enalapril is more effective than hydrochlorothiazide in reversing cardiovascular structural changes in essential hypertension, suggesting that structural reversal is more dependent on RAAS blockade than on blood pressure lowering alone.
Döhldf et al. (1992) studied this question.
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