Why the study?
Do ACE inhibitors (trandolapril or enalapril) reduce cardiac and vascular hypertrophy and improve survival in aged spontaneously hypertensive rats with heart failure?
Population
Old spontaneously hypertensive rats presenting with congestive heart failure.
Comparison
Trandolapril or enalapril for 3 months. vs Control group (untreated SHRs).
Design
Preclinical
Follow-up
3 months
Authors
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Reduces hypertrophy and mortality in aged hypertensive rat HF model; leaves open translation to human therapy.
Do ACE inhibitors (trandolapril or enalapril) reduce cardiac and vascular hypertrophy and improve survival in aged spontaneously hypertensive rats with heart failure?
In a rat model of heart failure, ACE inhibitors (particularly trandolapril) reduced cardiac and vascular hypertrophy and improved survival.
Secchi et al. (1994) studied this question.
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