Key result
Trandolapril extended the lifespan of a severe hypertensive rat model, with 0% mortality at 16 weeks compared to 85% mortality at 4 weeks with placebo, despite no reduction in blood pressure.
Authors
Loading...
Trandolapril extended rat lifespan independent of BP; hypothesis-generating for ACEI pleiotropy and leaves open human translation.
Absolute Event Rate: 0% vs 85%
Takai et al. (2001) studied Severe hypertension. Trandolapril vs. Placebo was evaluated on Mortality. Trandolapril extended the lifespan of a severe hypertensive rat model, with 0% mortality at 16 weeks compared to 85% mortality at 4 weeks with placebo, despite no reduction in blood pressure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: