Why the study?
Does perindopril improve blood pressure and lifespan in spontaneously hypertensive rats?
Population
Adult male spontaneously hypertensive rats (SHR) aged 15 weeks
Comparison
Perindopril 4 mg/kg once a day by gavage for 12… vs Distilled water
Design
Preclinical
Follow-up
Until death from natural causes
Authors
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Short-term perindopril may confer legacy BP control and longevity in hypertensive rats; leaves open translation to human hypertension.
Does perindopril improve blood pressure and lifespan in spontaneously hypertensive rats?
Short-term perindopril treatment in spontaneously hypertensive rats provides long-lasting blood pressure control and extends lifespan.
Lee et al. (1995) studied this question.
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