What does this research mean for the field?

Chronic treatment with the ACE inhibitor perindopril increases preglomerular renal vessel lumen diameter and reduces in vivo renal vasoconstrictor responsiveness in spontaneously hypertensive rats. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1998HypertensionOpen Access

Perindopril Treatment Affects Both Preglomerular Renal Vascular Lumen Dimensions and In Vivo Responsiveness to Vasoconstrictors in Spontaneously Hypertensive Rats

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Why the study?

Does perindopril improve renal vascular lumen dimensions and reduce vasoconstrictor responsiveness in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR) starting at 4 weeks of age

Comparison

Perindopril 3 mg/kg per day administered in… vs Untreated spontaneously hypertensive rats

Design

Preclinical

Follow-up

6 weeks (from 4 to 10 weeks of age)

Authors

GBGöran BergströmCardiac Imaging IJInger JohanssonKarolinska Institutet KSKathleen M. StevensonMonash University

Discussion

Member takes

Implication

Supports potential renal vascular remodeling with perindopril in hypertensive models; leaves open human translation and clinical relevance.

Structured PICO

Does perindopril improve renal vascular lumen dimensions and reduce vasoconstrictor responsiveness in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR) starting at 4 weeks of age

Intervention

Perindopril 3 mg/kg per day administered in drinking water from 4 weeks to 10 weeks of age

Comparator

Untreated spontaneously hypertensive rats

Outcome

Vessel lumen characteristics (assessed via maximally dilated in vitro isolated kidney perfusion) and renal vasoconstrictor responses to bolus doses of angiotensin II and phenylephrine in vivosurrogate

Chronic perindopril treatment in spontaneously hypertensive rats increases preglomerular renal vessel lumen diameter and reduces in vivo vasoconstrictor responsiveness, indicating vascular remodeling.

Cite This Study

Bergström et al. (1998) studied this question.

synapsesocial.com/papers/6a1d5bc473c56dd1bd2f92d8 https://doi.org/10.1161/01.hyp.31.4.1007

Topics

Hypertension management

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Implication

Supports potential renal vascular remodeling with perindopril in hypertensive models; leaves open human translation and clinical relevance.

Perindopril Treatment Affects Both Preglomerular Renal Vascular Lumen Dimensions and In Vivo Responsiveness to Vasoconstrictors in Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Perindopril Treatment Affects Both Preglomerular Renal Vascular Lumen Dimensions and In Vivo Responsiveness to Vasoconstrictors in Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider