Why the study?
Sympathetic activity, arteriolar structure, and angiogenesis modulate hypertension, but the effects of perindopril with or without exercise training on blood pressure control mechanisms remained to be analyzed.
Does perindopril combined with exercise training reduce blood pressure without inhibiting exercise-induced angiogenesis in spontaneously hypertensive rats?
Does perindopril combined with exercise training reduce blood pressure without inhibiting exercise-induced angiogenesis in spontaneously hypertensive rats?
Perindopril reduces blood pressure and sympathetic activity without inhibiting exercise-induced angiogenesis in spontaneously hypertensive rats, suggesting it is a suitable pharmacological option for hypertensive individuals who exercise.
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Rat findings on perindopril ± exercise require human validation; leaves open translation of BP mechanisms to clinical hypertension.
Miotto et al. (2020) studied this question.
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