Why the study?
Does perindopril have a persistent blood pressure lowering effect after treatment withdrawal in Milan hypertensive rats?
Does perindopril have a persistent blood pressure lowering effect after treatment withdrawal in Milan hypertensive rats?
The persistent blood pressure lowering effect of ACE inhibitors seen in spontaneously hypertensive rats after treatment withdrawal is not a general feature of genetic hypertension and may not be solely due to vascular structural changes.
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Perindopril withdrawal permits BP rebound in Milan rats despite vascular regression; challenges generalizability of ACEI legacy effects across genetic hypertension models.
Mulvany et al. (1991) studied this question.
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