What question did this study set out to answer?

To investigate the impact of ACE inhibitor treatment and its withdrawal on blood pressure and angiotensin peptides in spontaneously hypertensive rats.

September 1, 1995Journal of Cardiovascular Pharmacology

Converting Enzyme Inhibition and Its Withdrawal in Spontaneously Hypertensive Rats

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Why the study?

Does perindopril treatment and its withdrawal reduce blood pressure and alter angiotensin peptide levels in spontaneously hypertensive rats?

Population

Male spontaneously hypertensive rats (SHR) and normotensive Donryu rats

Comparison

Perindopril administered from 6 to 10 weeks… vs Vehicle

Design

Preclinical

Follow-up

Up to 20 weeks of age

Authors

DCDuncan J. CampbellHeart Failure & Transplant ADAnn-Maree DuncanAlbert Einstein College of Medicine AKAthena KladisSt Vincents Institute of Medical Research

Discussion

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Implication

Findings in SHR warrant clinical caution against extrapolation; hypothesis-generating for mechanisms of sustained BP effects after ACEi withdrawal.

Key Points

To investigate the impact of ACE inhibitor treatment and its withdrawal on blood pressure and angiotensin peptides in spontaneously hypertensive rats.
Young spontaneously hypertensive rats were treated with perindopril or vehicle.
Blood pressure and levels of angiotensin peptides were measured at 10 and 20 weeks of age.
The study assessed changes in plasma renin, angiotensinogen, ACE, and aldosterone after treatment and withdrawal.
Perindopril reduced blood pressure by 19 mm Hg after withdrawal in spontaneously hypertensive rats.
Plasma angiotensinogen was 14% lower in withdrawn SHR compared to vehicle-treated SHR (p = 0.0356).
Changes in angiotensin II levels were transient and did not persist after treatment cessation.

Structured PICO

Does perindopril treatment and its withdrawal reduce blood pressure and alter angiotensin peptide levels in spontaneously hypertensive rats?

Population

Male spontaneously hypertensive rats (SHR) and normotensive Donryu rats

Intervention

Perindopril (3 mg/kg/day) administered from 6 to 10 weeks, from 6 to 20 weeks, or from 6 to 10 weeks followed by withdrawal from 10 to 20 weeks

Comparator

Vehicle

Outcome

Blood pressure and levels of angiotensin-(1-7), angiotensin II, and angiotensin I in plasma and tissues (kidney, adrenal, heart, aorta, brown adipose tissue, lung, brain), plus plasma renin, angiotensinogen, ACE, and aldosterone at 10 and 20 weeks of agesurrogate

Early, transient ACE inhibition in spontaneously hypertensive rats produces a sustained reduction in blood pressure even after treatment withdrawal, possibly due to suppressed angiotensinogen or structural cardiovascular changes.

Cite This Study

Campbell et al. (1995) studied this question.

synapsesocial.com/papers/6a20e8326dd54ee3d3eb2454 https://doi.org/10.1097/00005344-199509000-00013

Topics

Hypertension management

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Implication

Findings in SHR warrant clinical caution against extrapolation; hypothesis-generating for mechanisms of sustained BP effects after ACEi withdrawal.

Converting Enzyme Inhibition and Its Withdrawal in Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Converting Enzyme Inhibition and Its Withdrawal in Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider