Key result
Chronic treatment with perindopril prevented the development of stroke and attenuated tissue damage in male stroke-prone spontaneously hypertensive rats.
Why the study?
Does perindopril prevent stroke and improve survival in male stroke-prone spontaneously hypertensive rats?
Does perindopril prevent stroke and improve survival in male stroke-prone spontaneously hypertensive rats?
Perindopril treatment prevents stroke and prolongs survival in stroke-prone hypertensive rats by preserving cerebral artery myogenic responses and attenuating tissue damage.
Authors
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Should not yet change practice; leaves open translation of stroke prevention from rat models to humans.
Lee et al. (1996) studied Stroke prevention in hypertension. Perindopril vs. Distilled water (control) was evaluated on Development of stroke and survival. Chronic treatment with perindopril prevented the development of stroke and attenuated tissue damage in male stroke-prone spontaneously hypertensive rats.
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