Population
Stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto rats (WKY)
Comparison
Perindopril, propranolol, or combination of… vs Untreated SHRSP and untreated WKY
Design
Preclinical
Follow-up
3 months
Authors
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May implicate pulse pressure reduction in reversing cerebral arteriolar hypertrophy in hypertension; hypothesis-generating for pressure-independent remodeling effects of ACE inhibitors.
In hypertensive rats, ACE inhibitors reduce cerebral arteriolar hypertrophy primarily by lowering pulse pressure, whereas their effects on arteriolar remodeling appear pressure-independent.
Chillon et al. (1999) studied this question.
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