Why the study?
Does the combination of delapril and indapamide improve survival and prevent vascular lesions in stroke-prone spontaneously hypertensive rats fed a high-sodium diet?
Population
Stroke-prone spontaneously hypertensive rats (SHRsp) fed a high-sodium diet from the eighth week of life
Comparison
Long-term treatment with the ACE inhibitor… vs Control rats (saline-treated)
Design
Preclinical
Follow-up
Until 50% mortality was reached in two treatment groups
Authors
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Animal data suggest delapril-indapamide synergy against hypertrophy; hypothesis-generating and should not yet change practice.
Does the combination of delapril and indapamide improve survival and prevent vascular lesions in stroke-prone spontaneously hypertensive rats fed a high-sodium diet?
The combination of delapril and indapamide synergistically prevents heart hypertrophy and better controls blood pressure in stroke-prone spontaneously hypertensive rats compared to either agent alone.
Biagini et al. (1997) studied this question.
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