Key result
Combined treatment with delapril and indapamide prevented aortic fibrosis in salt-loaded stroke-prone spontaneously hypertensive rats, independent of blood pressure reduction.
Why the study?
Does combined treatment with delapril and indapamide prevent aortic fibrosis in salt-loaded stroke-prone spontaneously hypertensive rats?
Population
Two-month-old salt-loaded stroke-prone spontaneously hypertensive rats (SHRsp)
Comparison
Combined treatment with delapril and indapamide… vs Delapril alone or indapamide alone
Design
Preclinical
Follow-up
5 months (or until 50% mortality or around midlife)
Authors
Loading...
May indicate BP-independent aortic protection in hypertensive models; leaves open translation to human disease.
Does combined treatment with delapril and indapamide prevent aortic fibrosis in salt-loaded stroke-prone spontaneously hypertensive rats?
The combination of delapril and indapamide limits aortic fibrosis in hypertensive rats independent of blood pressure reduction.
Contri et al. (2002) studied Hypertension. Combined delapril and indapamide vs. Delapril alone, indapamide alone, or lower dose combinations was evaluated on Extracellular matrix deposition (aortic fibrosis). Combined treatment with delapril and indapamide prevented aortic fibrosis in salt-loaded stroke-prone spontaneously hypertensive rats, independent of blood pressure reduction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: