Why the study?
Does combined treatment with perindopril and indapamide reduce blood pressure and improve cardiovascular structural remodeling in spontaneously hypertensive rats?
Population
Adult spontaneously hypertensive rats (SHR)
Comparison
Combined treatment with perindopril and… vs Placebo, perindopril alone, or indapamide alone
Design
Preclinical
Follow-up
12 weeks
Authors
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Should not change clinical practice; extends preclinical evidence for combination effects in hypertensive models.
Does combined treatment with perindopril and indapamide reduce blood pressure and improve cardiovascular structural remodeling in spontaneously hypertensive rats?
In a rat model of hypertension, low-dose combination of perindopril and indapamide provided superior blood pressure reduction and favorable cardiovascular structural remodeling compared to monotherapy.
Richard et al. (1996) studied this question.
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