June 1, 2001Journal of the Renin-Angiotensin-Aldosterone SystemOpen Access

Effects of combination of low doses of angiotensin-converting enzyme inhibitor and diuretics on renal function in spontaneously hypertensive rats: comparison between acute and chronic treatment

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Why the study?

Does combination therapy with perindopril and indapamide improve renal function in spontaneously hypertensive rats with moderate renal injury?

Population

Spontaneously hypertensive rats with moderate renal injury

Design

Preclinical

Authors

JDJ. DoucetHôpital Saint-Julien VRVincent RichardKuban State University PMPaul MulderUniversité Paris-Sud

Discussion

Member takes

Implication

Supports renal protection by perindopril-indapamide in hypertensive rat models; leaves open translation to human therapy.

Structured PICO

Does combination therapy with perindopril and indapamide improve renal function in spontaneously hypertensive rats with moderate renal injury?

Population

Spontaneously hypertensive rats with moderate renal injury

Intervention

S5590, a combination of perindopril (0.76 mg/kg/day) and indapamide (0.24 mg/kg/day) given as acute or chronic treatment

Outcome

Renal function (evaluated by clearance methods using labelled inulin and PAH)surrogate

In a rat model of hypertension, combination therapy with perindopril and indapamide normalized renal vascular resistance and maintained renal function.

Cite This Study

Doucet et al. (2001) studied this question.

synapsesocial.com/papers/6a7e8b9fc4fd4e6484338d2b https://doi.org/10.3317/jraas.2001.010

Topics

Hypertension management

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Effects of combination of low doses of angiotensin-converting enzyme inhibitor and diuretics on renal function in spontaneously hypertensive rats: comparison between acute and chronic treatment

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Effects of combination of low doses of angiotensin-converting enzyme inhibitor and diuretics on renal function in spontaneously hypertensive rats: comparison between acute and chronic treatment

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider