Why the study?
Does treatment with perindopril, indapamide, or their combination improve coronary microvascular alteration in hypertensive rats?
Population
Rats with renovascular hypertension induced by unilateral nephrectomy and renal artery stenosis and…
Comparison
Perindopril, indapamide, or the combination of… vs Untreated hypertensive rats and normotensive…
Design
Preclinical
Follow-up
4 weeks
Authors
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May extend microvascular remodeling evidence in hypertensive models; leaves open translation to human hypertension.
Does treatment with perindopril, indapamide, or their combination improve coronary microvascular alteration in hypertensive rats?
The combination of perindopril and indapamide normalizes blood pressure, cardiac hypertrophy, and coronary microvascular rarefaction in hypertensive rats.
B. I. Levy (2001) studied this question.
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